Question - Can genetic mutations be passed down?

Answered by: Timothy Turner  |  Category: General  |  Last Updated: 27-06-2022  |  Views: 564  |  Total Questions: 14

Gene mutations can be classified in two major ways: Hereditary mutations are inherited from a parent and are present throughout a person's life in virtually every cell in the body. Acquired mutations in somatic cells (cells other than sperm and egg cells) cannot be passed to the next generation. Some mutations are hereditary because they are passed down to an offspring from a parent carrying a mutation through the germ line, meaning through an egg or sperm cell carrying the mutation. There are also nonhereditary mutations that occur in cells outside of the germ line, which are called somatic mutations. Mutations can affect an organism by changing its physical characteristics (or phenotype) or it can impact the way DNA codes the genetic information (genotype). Of these specific types of mutations, they can be categorized into beneficial (helpful), less favorable (harmful), and non-effective (neutral) mutations. Mutations are random. Mutations can be beneficial, neutral, or harmful for the organism, but mutations do not "try" to supply what the organism "needs. " Factors in the environment may influence the rate of mutation but are not generally thought to influence the direction of mutation. Most disease-causing gene mutations are uncommon in the general population. However, other genetic changes occur more frequently. Genetic alterations that occur in more than 1 percent of the population are called polymorphisms. They are common enough to be considered a normal variation in the DNA.

https://www.newscientist.com/article/dn13673-evolution-myths-mutations-can-only-destroy-information/

TRIMming the genome The result is a hybrid protein called TRIM5-CypA, which can protect cells from infection with retroviruses such as HIV. Here, a single mutation has resulted in a new protein with a new and potentially vital function. New protein, new function, new information.

https://www.genome.gov/FAQ/Genetics-Disease-Prevention-and-Treatment

Your health care provider can then give you individualized and specific education about how to: Check regularly for the disease. Follow a healthy diet. Get regular exercise. Avoid smoking tobacco and too much alcohol. Get specific genetic testing that can help with diagnosis and treatment.

https://ghr.nlm.nih.gov/primer/mutationsanddisorders/neutralmutations

No; only a small percentage of mutations cause genetic disorders—most have no impact on health or development. For example, some mutations alter a gene's DNA sequence but do not change the function of the protein made by the gene.

https://www.ncbi.nlm.nih.gov/books/NBK21578/

Mutations arise spontaneously at low frequency owing to the chemical instability of purine and pyrimidine bases and to errors during DNA replication. Natural exposure of an organism to certain environmental factors, such as ultraviolet light and chemical carcinogens (e. g., aflatoxin B1), also can cause mutations.

https://www.amherst.edu/system/files/media/1857/ModGen_3B_SP.pdf

Either type of accident can result in a mutation, a heritable change in a gene. A DNA molecule that has been changed by mutation is normally just as stable and just as capable of faithful replication as it was before the mutation. Therefore, mutations can be passed on.

https://labtestsonline.org.au/learning/media-library/slide-presentations/cells-genes-signalling-part

Gene mutations also occur throughout life. They can result from copying mistakes made when the cell is dividing and replicating. They can also be caused by viruses, exposure to radiation (such as the sun) or chemicals (such as smoking). Mutations occur all the time and generally they have no impact.

http://theconversation.com/harmful-genetic-mutations-may-be-less-common-than-we-thought-94782

Beyond good and bad Often it depends on context, for example whether the mutation helps the organism use a particular food source or fight off a disease present during its lifetime. And some mutations can be beneficial if just one copy is inherited, but harmful if two copies are inherited.

http://www2.csudh.edu/nsturm/CHEMXL153/DNAMutationRepair.htm

There are three types of DNA Mutations: base substitutions, deletions and insertions. Base Substitutions. Single base substitutions are called point mutations, recall the point mutation Glu -----> Val which causes sickle-cell disease. Deletions. Insertions.

https://en.wikipedia.org/wiki/Adaptive_mutation

Adaptive mutation states that rather than mutations and evolution being random, they are in response to specific stresses. In other words, the mutations that occur are more beneficial and specific to the given stress, instead of random and not a response to anything in particular.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1931526/

When beneficial mutations are rare, they accumulate by a series of selective sweeps. But when they are common, many beneficial mutations will occur before any can fix, so there will be many different mutant lineages in the population concurrently.

https://www.sciencedaily.com/terms/genetic_code.htm

The genome of an organism is inscribed in DNA, or in some viruses RNA. The portion of the genome that codes for a protein or an RNA is referred to as a gene. Those genes that code for proteins are composed of tri-nucleotide units called codons, each coding for a single amino acid.

https://www.reactgroup.org/toolbox/understand/antibiotic-resistance/mutation-and-selection/

Mutations. Bacteria grow and multiply fast and can reach large numbers. When bacteria multiply, one cell divides into two cells. Mutations can also form due to external factors like radiation or harmful chemicals.

https://www.britannica.com/science/somatic-mutation

Somatic mutation, genetic alteration acquired by a cell that can be passed to the progeny of the mutated cell in the course of cell division. Somatic mutations differ from germ line mutations, which are inherited genetic alterations that occur in the germ cells (i. e., sperm and eggs).