Question - Can oligodendroglioma be cured?

Answered by: Laura Ward  |  Category: General  |  Last Updated: 24-06-2022  |  Views: 947  |  Total Questions: 14

In some cases, an oligodendroglioma can be cured. Anaplastic oligodendroglioma (grade III): An anaplastic oligodendroglioma grows quickly and spreads into nearby tissues. The tumor cells look different from normal cells. This type of tumor usually cannot be cured. As a general rule, people with grade II oligodendrogliomas are likely to live for around 12 years following diagnosis. People with grade III oligodendrogliomas are expected to live an average of 3. 5 years. There is a wide survival range which, in part, is related to tumor grade, with other factors contributing. Most low-grade tumors will eventually undergo transformation to more anaplastic forms, and the majority of patients with oligodendroglioma will ultimately die from the disease. Approximately one third of patients with oligodendroglioma appear to be cured with aggressive treatment. In many cases, they form years before being diagnosed as no symptoms appear. Grade III oligodendrogliomas are malignant (cancerous). This means they are fast-growing tumors. They are called anaplastic oligodendriogliomas.

https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=46484

The etiology is not known but no hereditary forms of oligodendroglioma have been reported. However, specific genetic characteristics, such as loss of chromosomes 1p and 19q, are observed.

https://www.cancer.gov/rare-brain-spine-tumor/tumors

Rare Brain and Spine Tumors Atypical Teratoid Rhabdoid Tumor (ATRT) ATRTs are very rare, fast-growing tumors that often occur in the brain and spread to the spinal cord. Choroid Plexus Tumors. Choroid plexus tumors can be slow- or fast-growing tumors. Diffuse Midline Gliomas. Ependymoma. Gliomatosis Cerebri. Gliosarcoma. Medulloblastoma. Meningioma.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846213/

Although oligodendroglioma are sometimes considered relatively benign because of their initial indolent disease course, they are almost invariably fatal. Most oligodendroglioma occur in the cerebral white matter, but they can be found anywhere in the central nervous system.

https://oncologypro.esmo.org/education-library/factsheets-on-biomarkers/1p-19q-co-deletion-in-glioma

Definition of 1p/19q co-deletion This molecular alteration is the result of an unbalanced whole-arm translocation between chromosomes 1 and 19 3 with the loss of the derivative t(1p;19q), which occurs early in the pathogenesis of oligodendrogliomas.

https://academic.oup.com/neuro-oncology/article/14/4/518/1053145

Glioblastoma (GBM) is the most malignant grade of astrocytic tumor (astrocytoma grade IV). However, a subset of GBM (4%–20%)1–4 contains foci that resemble oligodendroglioma and were classified as GBM with an oligodendroglioma component (GBMO), according to the 2007 World Health Organization classification.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338899/

Despite improved surgical techniques, therapies and radiotherapies, prognosis for this type of pathology remains very poor: most patients die within 12–18 months from diagnosis. There is however a small percentage of Patients affected by glioblastoma multiforme who survive 3 years or longer,.

https://www.clinicaloncologyonline.net/article/S0936-6555(15)00162-4/pdf

1p19q co-deletion is a chromosomal alteration associated with primary brain tumours of oligodendroglial histology. It is an established predictive and prog- nostic biomarker that informs whether patients are offered radiotherapy, chemotherapy or both.

https://www.abta.org/wp-content/uploads/2018/03/glioblastoma-brochure.pdf

The pathological diagnosis is based on appearance of cells (nuclear atypia) and growth rate (mitotic activity). Glioblastoma is still often abbreviated “GBM” is the highest grade glioma (grade IV) tumor, is the most malignant form of astrocytoma, and is synonymous with a grade IV glioma.

https://www.emedicinehealth.com/brain_cancer/article_em.htm

The long-term survival rate (life expectancy greater than five years) for people with primary brain cancer varies. In cases of aggressive or high-grade brain cancers it is from less than 10% to about 32%, despite aggressive surgery, radiation, and chemotherapy treatments.

https://www.mayoclinic.org/diseases-conditions/brain-tumor/symptoms-causes/syc-20350084

Primary brain tumors begin when normal cells acquire errors (mutations) in their DNA. These mutations allow cells to grow and divide at increased rates and to continue living when healthy cells would die. The result is a mass of abnormal cells, which forms a tumor.

https://en.wikipedia.org/wiki/Oligodendroglioma

Oligodendroglioma. Oligodendrogliomas are a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell. They occur primarily in adults (9. 4% of all primary brain and central nervous system tumors) but are also found in children (4% of all primary brain tumors).

https://www.thebraintumourcharity.org/understanding-brain-tumours/getting-a-diagnosis/prognosis/prog

High grade/anaplastic (grade 3) About 30 to 38% of people with this type of tumour will survive for 5 years or more after they are diagnosed. Read more about oligodendroglioma brain tumour types and treatments.

https://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/prognosis-and-survival/survival

Anaplastic or malignant meningioma (grade 3) – These tumours have a median survival of less than 2 years. The median progression-free survival is approximately 12. 8 months with chemotherapy alone and up to 5 years with combination chemotherapy and radiation therapy. Median survival ranges from 7–24 weeks.

https://www.medicinenet.com/brain_tumor_symptoms/views.htm

Rarely are benign tumors untreatable. Survival in children for all brain tumors is about 70%; long-term side effects (for example, vision problems, speech problems, decreased strength) are common. For adults, five-year survival is related to age group, with younger ages (20-44) surviving at about a 50% rate.