Question - Can omeprazole affect your pancreas?

Answered by: Lawrence Perry  |  Category: General  |  Last Updated: 24-06-2022  |  Views: 661  |  Total Questions: 14

PPIs have minimal side effects and few significant drug interactions. They are generally considered safe for long-term treatment. We present a rare side effect, acute pancreatitis, occurring in a patient who was treated with the proton pump inhibitor omeprazole. Proton pump inhibitors–induced acid suppression leads to elevated gastrin levels that have been suggested as underlying mechanism of pancreatitis in these cases. Direct stimulatory effect of gastrin increases secretion of pancreatic enzymes, eventually resulting in pancreatitis. PPIs may be associated with an increased risk of pancreatic cancer. -PPI use is not associated with survival in pancreatic cancer patients. -PPIs should be prescribed judiciously but not withheld in patients with pancreatic cancer. Omeprazole may help your stomach symptoms related to acid, but you could still have serious stomach problems. This medication may increase your risk of severe diarrhea. This diarrhea may be caused by an infection (Clostridium difficile) in your intestines. ACE Inhibitors Other case reports about pancreatitis induced by lisinopril (13, 28, 42, 53), captopril (38), ramipril (41)and perindopril (27) have been also published. In one case-control study, the use of ACE inhibitor was associated with an increased risk of acute pancreatitis, with an odds ratio of 1. 5.

http://www.cnn.com/2010/HEALTH/expert.q.a/11/03/chronic.pancreatitis.brawley/index.html

Drugs to lower gastric acidity are also useful. This can be either an H2 receptor blocker such as ranitidine or a proton pump inhibitor such as omeprazole. These drugs reduce the inactivation of the supplemental pancreatic enzymes from gastric acid. Treatment of chronic pancreatitis can also be aimed at its cause.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544058/

Although acid-suppressing drugs (H2-antagonists or proton-pump inhibitors) and gastroesophageal reflux disease are risk factors for acute pancreatitis [4], we felt that the addition of a new drug (furosemide) was more likely the cause of the acute pancreatitis versus a medication that the patient had been taking

https://my.clevelandclinic.org/health/diseases/17319-pancreatitis-acute--chronic-overview

Medications that can cause acute pancreatitis include: Azathioprine. Thiazide. Valproic acid. Dideoxyinosine. Sulfasalazine. Trimethoprim-sulfamethoxazole. Pentamidine. Tetracycline.

https://www.biotherapy-clinic.com/chronic-pancreatitis-and-bile-reflux.html

Chronic pancreatitis and bile reflux. The majority of patients with pancreatic problems suffer from heartburn. In 70% of the chronic cases of heartburn and Barrett's Esophagus there is bile reflux. Barrett's Esophagus is a serious precancerous complication of GERD.

https://www.the-hospitalist.org/hospitalist/article/123510/avoid-pancreatitis-risk

The following drugs/classes have been implicated in causing DIP: AIDS therapies: ddI, pentamidine; Antimicrobials: metronidazole, sulfonamides, tetracyclines; Diuretics: furosemide, HCTZ; Anti-inflammatories: mesalamine, salicylates, sulindac, sulfasalazine;

https://pancreasfoundation.org/patient-information/chronic-pancreatitis/chronic-pancreatitis-pain-ma

Chronic Pancreatitis Pain Management and Treatment Pain medication begins with nonopioids (like acetaminophen, ibuprofen, or both). If nonopioids do not relieve pain, mild opioids (like codeine) are given. If mild opioids do not relieve pain, strong opioids (like morphine) are given.

https://www.merckmanuals.com/home/digestive-disorders/pancreatitis/chronic-pancreatitis

Alcohol use and cigarette smoking are two major causes of chronic pancreatitis. Abdominal pain may be persistent or come and go. The diagnosis is based on the symptoms, a history of recurring acute pancreatitis and alcohol use, imaging tests, and pancreatic function tests.

https://www.researchgate.net/publication/7397766_Acute_pancreatitis_associated_with_omeprazole

Proton pump inhibitors (PPIs) could inhibit the secretion of gastric acid. Meanwhile, it could also decrease the secretion of other digestive glands besides gastric parietal cell. As we know, PPIs have been widely used to treat acute pancreatitis, and it is effective in clinical practice.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761557/

In contrast, the option of long-term PPI therapy was associated with a significant body weight gain in the present study. Omeprazole and other PPIs delay gastric emptying[6-9], which induces postprandial fullness, dyspeptic symptoms, gastrointestinal bacterial overgrowth, and subsequent weight loss[10, 11].

https://www.nhs.uk/medicines/omeprazole/

It's usual to take omeprazole once a day in the morning. For severe illness, you can take it twice a day - in the morning and in the evening. Common side effects include headaches, diarrhoea and stomach pain. If you're self-treating with omeprazole, do not take it for longer than 2 weeks without checking with a doctor.

https://www.everydayhealth.com/ibs/living-with-ibs-and-gerd.aspx

Irritable bowel syndrome, or IBS, causes belly pain along with changes in bowel habits, either diarrhea or constipation. Gastroesophageal reflux disease, or GERD, causes acid reflux, commonly referred to as heartburn. Having one of these conditions can be bad enough, but many people have to deal with both.

https://www.everydayhealth.com/drugs/prilosec

Prilosec Interactions Certain antibiotics, such as ampicillin (Principen, Unasyn) Anticoagulants (often called "blood thinners") such as warfarin (Coumadin, Jantoven), rivaroxaban (Xarelto), and apixaban (Eliquis). Atazanavir (Reyataz) Benzodiazepines such as diazepam (Valium) Cilostazol (Pletal) Clopidogrel (Plavix)

https://www.healthline.com/health/omeprazole-oral-capsule-sprinkles

Omeprazole side effects Adult side effects can include: headache. stomach pain. nausea. diarrhea. vomiting. gas. Children's side effects can include the above, plus the following: fever.

https://www.drugwatch.com/proton-pump-inhibitors/alternatives/

These include proton pump inhibitors such as esomeprazole (Nexium), omeprazole (Prilosec), pantoprazole (Protonix) and lansoprazole (Prevacid). The others are antacids such as Maalox, Mylanta and Tums; and H2 (histamine) receptor antagonists such as ranitidine (Zantac), famotidine (Pepcid), and cimetidine (Tagamet).