Question - What does the suffix MAB mean?

Answered by: Howard Nelson  |  Category: General  |  Last Updated: 24-08-2021  |  Views: 729  |  Total Questions: 14

The suffix "-mab" is used for monoclonal antibodies, antibody fragments and radiolabeled antibodies. For polyclonal mixtures of antibodies, "-pab" is used. The -pab suffix applies to polyclonal pools of recombinant monoclonal antibodies, as opposed to polyclonal antibody preparations isolated from blood. Medical Definition of MAB Abbreviation for monoclonal antibody. At the end of a generic drug name, -mab indicates that the drug is a monoclonal antibody. As in adalimumab, bevacizumab, infliximab, rituximab, and trastuzumab. UMAB. Acronym. Definition. UMAB. In general, word stems are used to identify classes of drugs, in most cases placed word-finally. All monoclonal antibody names end with the stem -mab. Unlike most other pharmaceuticals, monoclonal antibody nomenclature uses different preceding word parts (morphemes) depending on structure and function. A MAB works by recognising and finding specific proteins on cells. Some work on cancer cells, others target proteins on cells of the immune system. Each MAB recognises one particular protein. They work in different ways depending on the protein they are targeting.

https://en.wikipedia.org/wiki/Monoclonal_antibody_therapy

Human monoclonal antibodies (suffix -umab) are produced using transgenic mice or phage display libraries by transferring human immunoglobulin genes into the murine genome and vaccinating the transgenic mouse against the desired antigen, leading to the production of appropriate monoclonal antibodies.

https://uniontestprep.com/teas/blog/common-blood-pressure-medications

Works by: Making the heart beat slower and less forcefully, which in turn lowers blood pressure. Typical suffix: -olol. Common Drugs: Metoprolol (Lopressor, Toprol-XL) Atenolol (Tenormin) Propranolol (Inderal LA, InnoPran XL) Bisoprolol (Zebeta)

https://www.medicinenet.com/monoclonal_antibodies/article.htm

Here is a list of examples some FDA-approved monoclonal antibody drugs. abciximab (Reopro) adalimumab (Humira, Amjevita) alefacept (Amevive) alemtuzumab (Campath) basiliximab (Simulect) belimumab (Benlysta) bezlotoxumab (Zinplava) canakinumab (Ilaris)

https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/targeted-cancer-drugs/type

All MABs have names that include 'mab' at the end of their generic name, for example: trastuzumab (Herceptin) pertuzumab (Perjeta) bevacizumab (Avastin) rituximab (Mabthera)

https://medical-dictionary.thefreedictionary.com/-zumab

-zumab. A suffix for humanized monoclonal antibody. Antibodies made from -zumabs are less likely than -ximabs to elicit a neutralizing antibody response in the patient who receives them.

https://en.wikipedia.org/wiki/Drug_nomenclature

Drug nomenclature is the systematic naming of drugs, especially pharmaceutical drugs. Generic names for drugs are nowadays constructed out of affixes and stems that classify the drugs into different categories and also separate drugs within categories. A marketed drug might also have a company code or compound code.

https://www.medscape.com/viewarticle/867446_3

The 'Nibs' The suffix "nib" indicates a small-molecule inhibitor ("nib" is verbal shorthand for "inhibit") of kinase enzymes. More specifically, "tinib" is used for tyrosine kinase inhibitors, "anib" for angiogenesis inhibitors, and rafenib for rapidly accelerated fibrosarcoma (RAF) kinase inhibitors.

https://www.medicinenet.com/script/main/art.asp?articlekey=10127

Generic name, drug: The term "generic name" has several meanings as regards drugs: The chemical name of a drug. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug is sold. A term referring to any drug marketed under its chemical name without advertising.

https://journalofethics.ama-assn.org/article/how-do-drugs-get-named/2019-08

Pharmaceutical names are assigned according to a scheme in which specific syllables in the drug name (called stems) convey information about the chemical structure, action, or indication of the drug.

https://www.fda.gov/drugs/data-standards-manual-monographs/use-drug-name-terms-policy

Official Name: The name designated under the provisions of section 508(a) of the Federal Food, Drug, and Cosmetic Act. Official Preparation: A drug product, a nutritional supplement or a finished device.

https://www.rxlist.com/consumer_acetaminophen_tylenol/drugs-condition.htm

Acetaminophen is available under the following different brand names: Tylenol, Tylenol Arthritis Pain, Tylenol Ext, Little Fevers Children's Fever/Pain Reliever, Little Fevers Infant Fever/Pain Reliever, and PediaCare Single Dose Acetaminophen Fever Reducer/Pain Reliever.

https://www.healthinsurance.org/glossary/brand-name-drug/

What is a brand-name drug? Prescription drugs marketed with a specific brand name by the company that manufactures it, usually the company which develops and patents it. When patents run out, generic versions of many popular drugs are marketed at lower cost by other companies.

https://discoveryplace.info/addiction-blog/alcohol-opioids-and-barbiturates-oh-my-the-six-classifica

When considering only their chemical makeup, there are six main classifications of drugs: alcohol, opioids, benzodiazepines, cannabinoids, barbiturates, and hallucinogens. Out of all the thousands of drugs that are out there, both prescription and illegal, each one can be categorized under one of these six headings.