Question - When was Librium invented?

Answered by: Gloria Murphy  |  Category: General  |  Last Updated: 20-06-2022  |  Views: 1475  |  Total Questions: 14

The first benzodiazepine, chlordiazepoxide (Librium), was introduced in 1960. This was followed in 1963 by diazepam (Valium), the archetypal compound from which many derivatives were synthesized. The drug has amnesic, anticonvulsant, anxiolytic, hypnotic, sedative and skeletal muscle relaxant properties. Chlordiazepoxide was patented in 1958 and approved for medical use in 1960. Chlordiazepoxide. Clinical data Trade names Librium, others AHFS/Drugs. Librium is well absorbed, with peak blood levels being achieved one or two hours after administration. Steady-state levels are usually reached within three days. Librium is a benzodiazepine, which is a class of drugs that slows down brain activity to reduce symptoms of anxiety. People often wonder if since Librium can be used for alcohol withdrawal whether or not Librium has uses in withdrawal of narcotics. Below is information about this question.

https://en.wikipedia.org/wiki/Benzodiazepine

The first such drug, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955, and made available in 1960 by Hoffmann–La Roche, which, since 1963, has also marketed the benzodiazepine diazepam (Valium).

http://www.nbcnews.com/id/44503268/ns/health-addictions/t/winehouses-death-points-dangers-detoxing-a

It's not known whether Librium contributed to Winehouse's death, but Dr. Librium can become addictive and can cause medical issues such as dependence, agitation, disorientation, hypertension, anxiety and anorexia if it's taken much longer than a week.

https://www.addictioncenter.com/benzodiazepines/librium/

Librium Addiction. Like other benzodiazepines, Librium is a habit-forming, psychotropic drug. Users who are prescribed Librium for a legitimate medical purpose, like to treat insomnia or anxiety, can still develop a dependence on the drug.

https://www.webmd.com/drugs/2/drug-5263/librium-oral/details

The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems.

https://www.rxlist.com/librium-side-effects-drug-center.htm

Common side effects of Librium include: drowsiness, tiredness, dizziness, nausea, vomiting, constipation, blurred vision, swelling,

https://en.wikipedia.org/wiki/Tranquilizer

Tranquilizer. Tranquilizer, as a term, was first used by F. F. Yonkman (1953), from the conclusions of investigative studies using the drug Reserpine, showed the drug had a calming effect on all animals it was administered to. Reserpine, is a Centrally Acting Rauwolfia Alkaloid.

https://en.wikipedia.org/wiki/Meprobamate

Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug.

https://en.wikipedia.org/wiki/Mother%27s_Little_Helpers

From Wikipedia, the free encyclopedia. Mother's Little Helpers or Mother's Little Helper may refer to: Nickname for the drug Diazepam (Valium) Cougars, Inc., developed under the title Mother's Little Helpers, a 2010 indie film. "Mother's Little Helper", a 1966 Rolling Stones song.

https://www.everydayhealth.com/drugs/librium

Librium is the brand name of the prescription drug chlordiazepoxide, which is used to treat anxiety disorders and withdrawal symptoms associated with alcoholism. The medicine is sometimes used in patients to reduce anxiety before a surgical procedure. It's also used to treat symptoms of irritable bowel syndrome.

https://www.merseycare.nhs.uk/media/2139/chlordiazepoxide-2014.pdf

Chlordiazepoxide is normally used for short periods of time, usually a few days and less than 4 weeks, to prevent you becoming used to it and reduce the risk of addiction. Discuss with your doctor how long you will need to be on this medication.

https://www.withdrawal.net/sedative/librium/

Librium has a long elimination life, allowing the drug to stay in the body even after days of ingestion. The usual half-life of Librium is 5 to 30 hours, but it has an active metabolite with a half-life of 36 to 200 hours.

https://www.nami.org/learn-more/treatment/mental-health-medications/lithium

Bipolar disorder requires long-term treatment. Do not stop taking lithium, even when you feel better. Missing doses of lithium may increase your risk for a relapse in your mood symptoms. Do not stop taking lithium or change your dose without talking to with your healthcare provider first.

https://www.medicinenet.com/ativan_lorazepam_vs_librium_chlordiazepoxide/article.htm

Ativan (lorazepam) and Librium (chlordiazepoxide) are benzodiazepines used to manage anxiety disorders, before anesthesia for sedation, and to prevent and treat alcohol withdrawal.

https://www.everydayhealth.com/bipolar-disorder/stopping-bipolar-disorder-drugs.aspx

If you suddenly stop taking lithium, one of the drugs most commonly prescribed to stabilize bipolar disorder moods, you can experience “rebound, ” a worsening of your bipolar symptoms. “If those drugs are stopped suddenly, symptoms can come back even more severe than they were at the start. ”